N° 01
AI-native methodology
Built around modern machine learning, not retrofitted onto legacy workflows.
Why ProtoVela
Section · N° 04
The advantages of computational-first biotech
ProtoVela was founded on a simple belief: the next wave of protein innovation will be designed, not just discovered. Here's why partners choose us.
N° 02
Deep scientific roots
Founded by a scientist with decades of experience in membrane proteins, VDAC structural analysis, X-ray crystallography and protein chemistry.
N° 03
Cost-efficient
No wet-lab overhead — predictive in silico work dramatically reduces cost per iteration.
N° 04
Faster timelines
Reducing wet lab iterations through in silico design — iterate in days, not months. Move from concept to validated design at startup speed.
N° 05
Tangible deliverables
Designs that translate — ready for your team to express, test and validate.
N° 06
Trusted partnership
Transparent collaboration, clear documentation and full IP ownership in generative protein design — all rights remain with the customer.
The Promise
We help you overcome one of biotech's biggest hurdles — protein stability.
With ProtoVela, your proteins become market-ready faster and more reliable. We bring your most challenging molecules into the realm of the possible.
Optimization Targets
Six protein properties we target by design
Every ProtoVela design pipeline can be tuned toward the parameters that matter most for your molecule and your market.
N° 01
Producibility
Higher recombinant expression yield through sequence optimization in the appropriate host system — fewer batches, lower cost per gram of protein.
N° 02
Colloidal stability
Reduced aggregation and improved behaviour at high concentrations for formulation and storage.
N° 03
Thermal stability
Elevated melting temperature (Tm) — proteins that survive process, transport and shelf conditions.
N° 04
Long-term stability
Engineered for extended shelf life under realistic storage conditions.
N° 05
Proteolytic stability
Resistance to enzymatic degradation — critical for in vivo half-life and downstream processing.
N° 06
Patentability
Sequence space designed for clean IP — distinct from prior art and ready for protection.
Design Process
Our 8-step design strategy
A structured pipeline from client sequence to delivered candidate set — fully in silico, ready for wet-lab validation.
- STEP · 0101
Sequence analysis
In-depth assessment of the client's target sequence and project goals.
- STEP · 0202
Structural search
Identification of related and homologous structures from public and proprietary databases.
- STEP · 0303
De novo generation
Generation of candidate de novo structures where no suitable template exists.
- STEP · 0404
Residue selection
Identification of critical residues — catalytic, structural, interface and stability hotspots.
- STEP · 0505
AI-driven optimization
Sequence optimization combining generative models, evolutionary signal and physics-based scoring.
- STEP · 0606
Computation & analysis
In silico validation of each design — energetics, dynamics and predicted properties.
- STEP · 0707
Success assessment
Ranking of designs against the original target profile and feasibility criteria.
- STEP · 0808
Selection for DSP
Curated set of sequences delivered for cloning, expression and downstream processing.
N° 01
∞
Data-driven insights
Limitless computational power applied to molecular discovery.
N° 02
100%
Focus on innovation
Entirely in silico approaches — no wet lab dependencies.
N° 03
30+
Years scientific experience
Combined leadership rooted in protein science and structural biology.
Let's collaborate
Your gateway to more stable, optimized proteins.
We help you overcome one of biotech's biggest hurdles — protein stability. With ProtoVela's in silico stability optimization and in silico drug discovery partnerships, your proteins become market-ready faster and more reliable.
Keep reading · Sitemap
Explore further
Five entry points into ProtoVela — from process and proof to the intro call.
N° 01
Expertise
Services, molecule classes and scientific application areas in detail.
N° 02
Why ProtoVela
Principles, optimisation targets and the eight-step design process.
N° 03
About
Team, location and scientific leadership behind ProtoVela.
N° 04
Blog
Field notes on AI, structural biology and protein design.
N° 05
Contact
Book a free intro call and Project Assessment.